Pakistan hit back with two wickets after England seamers Stuart Broad and James Anderson shot out the series winner for 99 on the first day of the third and final test on Friday (UK time).
Broad bulldozed the top order with 4-36 and Anderson captured 3-35 before Umar Gul's brace left England in trouble at 19-2 at tea.
Jonathan Trott could have survived had he used video review but the batsman chose to walk after scoring 2 as replays suggested Gul's delivery would have missed the leg stump.
Captain Andrew Strauss square cut Saeed Ajmal to backward point for a boundary in the last over before tea and was unbeaten on 9 with Kevin Pietersen not out on 6.
Gul had England in early trouble when he Alastair Cook, on 1, offered a thick outside edge in only the second over after Pakistan was bowled out for its sixth lowest ever total in a test match against England.
James Anderson, who had struck in his very first over in the morning, ensured Pakistan did not reach 100 when he closed the innings by clean-bowling Gul midway into the second session.
Earlier, skipper Misbah-ul-Haq's decision to bat first after winning the toss backfired and Pakistan could never recover after Broad and Anderson reduced Pakistan to 21-5 within the first hour.
Asad Shafiq fought a lone battle with 45 off 78 balls before he was trapped lbw by left-arm spinner Monty Panesar (2-25).
The 34-run eighth-wicket stand between Shafiq and Ajmal (12) ensured Pakistan passed its lowest ever score of 53 made against Australia in 2002 at Sharjah.
Shafiq pulled Broad to the midwicket boundary to also take Pakistan past its lowest score of 72 against England at Birmingham two years ago.
Pakistan had a disastrous start at the same venue where it defeated England by 10 wickets last month.
Anderson had opener Taufeeq Umar lbw for a duck off his sixth delivery and Broad was unlucky not to get rid of Mohammad Hafeez in the next over when Strauss at first slip dropped a two-handed head-high catch.
But Broad did not have to wait long for his reward, striking three times in the space of 16 balls as Pakistan crumbled.
He succeeded on both of his TV referrals after Australian umpire Simon Taufel had adjudged Azhar Ali (1) and Hafeez (13) not out.
Hafeez could face some action from match referee Jeff Crowe after he sarcastically clapped with his bat while walking back to the dressing room after his lbw decision was overturned by TV umpire Shahvir Tarapore.
In between those successful replay challenges, Broad snared Younis Khan, who flashed at a wide delivery on 4 and edged through to wicketkeeper Matt Prior.
Anderson reduced Pakistan to 5-21 when he had Misbah trapped lbw for 1 as he missed while trying to play across the line.
Strauss, who saw his batsmen fall well short of a modest victory chase of 145 runs in the second test at Abu Dhabi last week, kept the pressure on Pakistan and Broad took his fourth wicket by having Adnan Akmal lbw for 6.
Graeme Swann was also amongst the wickets in his only over bowled before the break, with Pietersen at mid-off neatly holding onto a skier from Abdur Rehman, out for 1.
Pakistan brought back fast bowler Aizaz Cheema in place of Junaid Khan while England surprisingly kept faith in the same batting lineup that flopped in the two defeats.
Pakistan has an unassailable 2-0 lead in the three-match series after winning the first two tests by 10 wickets and by 72 runs respectively.
Top-ranked England needs to win the last test to ensure it pockets the ICC's $175,000 prize money awarded to the No. 1 test team on each April 1.
AP