The 'Edge of Love' star will grace the front page of the July edition of the style bible, despite being ridiculed by staff the last time she was featured.
The actress-turned-fashion designer has been in Los Angeles for a photoshoot for the magazine, proving she bares no hard feelings after she was criticised for having unruly hair and bad teeth.
Sienna appeared in 'The September Issue', a documentary following legendary US Vogue editor Anna Wintour as she put out the September 2007 edition of the publication.
During the programme, staff are seen despairing of the actress, who starred on the magazine's cover.
One viewer said: "It must be awful for Sienna to see. Anna keeps complaining she is too 'toothy' and the other staff are worried she has too many fillings.
"The editors hint at Sienna to cut her hair and she ignores them, which worried them even more. It was funny, but probably not for her."
Bang! Showbiz