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Pain relievers Paradex, Capadex to be withdrawn

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A review concluded that the medications were no better at treating pain than taking full dose paracetamol (file pic)

A review concluded that the medications were no better at treating pain than taking full dose paracetamol (file pic)

Tue, 09 Feb 2010 2:34p.m.

Medicines containing dextropropoxyphene are being withdrawn from the New Zealand market after a review showed that their risks outweighed their possible benefits.

The medicines containing it are analgesics used to treat chronic moderate pain. There are two approved for use in New Zealand - Paradex tablets and Capadex capsules.

After reviewing the available evidence, the Medicines Adverse Reactions Committee (MARC), which advises the Minister of Health on medicines safety issues, concluded that they were no better at treating pain than taking full dose paracetamol.

They could also cause additional side effects to those caused by paracetamol used at recommended doses, and were dangerous in overdose, or if they were taken with alcohol.

Medsafe group manager Stewart Jessamine said the withdrawal would be gradual to allow time for the safe transfer of patients to alternative treatments.

Medicines containing dextropropoxyphene have been withdrawn in several other countries, most notably the United Kingdom. The European Medicines Agency and Singapore have recently announced that they are also withdrawing these medicines.

When dextropropoxyphene was withdrawn in the United Kingdom it was replaced with other pain killers, mostly by paracetamol alone, codeine alone, or a combination of codeine and paracetamol.

Dr Jessamine said any patient who was currently being treated with Paradex or Capadex should continue to take their medicines. Those who regularly take them would need to see their GP to discuss alternative treatment options.

NZPA

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Comments [16]

Howard
04 Aug 2010 9:56a.m.

Hi all, i'm head on car smash, Brain injury, 5 ribs ,broken arm and a bit of whiplash for icing. I am nearly 9 years on Paradex and it literally keeps me from falling off my perch with windows of clarity and intelligence which I value. Lets all contact Marko and see if we, the majority, can't stop the knee jerk reactionary, powers that be crippling the people its designed to help by imposing minority rule.I'm going to.If its not broken don't fix it.

Tony
19 Jul 2010 11:04p.m.

I really feel for you good people out there but there may be a degree of hope. I collected my last 240 subsidised tabs of Paradex today but discovered wth the help of a friendly pharmacist that there is provision within the Medicines Act (sec 29) that those in real need can be placed on a special list and continue to receive their Paradex at an unsubsidised rate of $12.50/100. A doctor's prescription would still be required as usual. I suggest you check this out with your pharmacy although I have had it confirmed by two outlets. Purely as a matter of interest, I should mention that around 10% of those of northern European ancestory lack the essential liver enzymes to convert codeine-based products into morphine and hence no relief. Stewart Jessamine of MedSafe would appear to be unaware of that. The enzyme number is CYP2D6.

I wish you all the best of luck but please do your own personal checking first and choose the friendliest pharmacist in the shop!

agg
08 Jun 2010 10:23a.m.

i am so desperate i had been onn anti depressants for years i believe they destroyed me till i stumbled upon paradex for the first time in my life i can funtion i also have back and neck injuries im devastated they have taken this off the market if they only new the damage they are doing head up people

Talitha
31 May 2010 3:27p.m.

I have taken paradex for chronic back pain for 10 years, and for migraines for around 20 years, common paracetamol doesnt even begin to touch it! Codiene doesnt even work anywhere near as good - all our bodies react differently. My only alternative is the more expensive tramal... just what I need... And that doesnt even work as good for me as paradex! Geez not to mention the damage taking high doses of paracetamol (wich we will inevadibly do to try to kill the pain) will do to our livers etc... FFS These people are morons! >:(

Dot
14 May 2010 5:00a.m.

Who does ‘MARC’ and the Minister of health think they are, to come to the conclusion, that paradex it is no better than paracetamol. They should not be given these positions, if they cannot tell the difference!!!!

Arrow
29 Mar 2010 2:44p.m.

I have relied on Capadex (Paracetamol+Dextropropoxyphene)the past 20years. It not only takes away pain but also improves my emotions. Have never taken more than 4 in a day and usually only 2. Never had any problems at all with it's use. Very angry to be dictated to about what medication I may or may not use or have access too. At a certain age (late fifties) one comes to realise that even if one did become addicted to a medication, one should be able to choose that course of action.

Marko
22 Mar 2010 12:41p.m.

Just over a year ago I had a major back operation and bone graft in my lower back. My surgeon put me onto Paradex and Codeine together which has been super effective. I had doctors try and tell me firstly that I should get off the codeine as it WILL stop me up (bowels) which has never happened, and that I should get off Paradex asap as it is very dangerous for my liver. Ok so I have had liver function tests and they aren't so good but that is because of my daily alcohol intake (beer) which I also medicate with. So here is my take on the mixture of Condeine (60mg) + Paradex x 2 every four hours. It WORKS! I can get through the day feeling reasonably well without being in agony. I think we should get together and fight the Government on this one. If you are interested, contact me on elvin66@xtra.co.nz and I will get something going. Hang in there !

Tony
16 Mar 2010 3:13p.m.

I have been on Digesic followed by the generic Paradex for 30 years for some effective control of clustered migraines and then for pain control after a knee joint replacement. I should mention that post-operative treatment of morphine gave no relief at all and I discharged myself within 24 hours to avail myself of Paradex which gave me immediate relief and has continued to do so as the operation was not completely successful. I see that the MARC meeting voted against Paradex 14/12 so just one lousey vote has condemned 78,000 people to a miserable future who will, no doubt, take this into consideration at the ballot box. It may be of interest to mention that when Britain banned Co-Proxamol in 2005, those on this Paradex equivalent were given until 2008 to adjust but to adjust to what? Personally, I find like the rest of you that paracetamol to be of no more use than powdered chalk, codeine useless and the same for Acupan and the expensive Tramadol. Do the MARC people really know what they are about?

MargoJH
12 Mar 2010 7:34p.m.

Those of us that cannot use codeine will just be left to endure the pain or switch to something that is more addictive. For me it probably will see me loose my job as I will not be able to work without effective pain relief. Back to the Invalids Benefit which will cost the Govt more than paradex

kevan
20 Feb 2010 12:37p.m.

Hi people, I have been on Paradex for about 18years because of low back and leg pain. This helps about 60% of the pain and the ONLY way I'm addicted is, THAT IT WORKS, no real other side affects. If Paradex is taken away I'm left going to stuff that contains morphine ect that is bound to make me dependent.Codeine gives me headaches and I have tried most of the other pain killers with no joy. What's next for us??

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