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Pain relievers Paradex, Capadex to be withdrawn

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Tue, 09 Feb 2010 2:34p.m.

Medicines containing dextropropoxyphene are being withdrawn from the New Zealand market after a review showed that their risks outweighed their possible benefits.

The medicines containing it are analgesics used to treat chronic moderate pain. There are two approved for use in New Zealand - Paradex tablets and Capadex capsules.

After reviewing the available evidence, the Medicines Adverse Reactions Committee (MARC), which advises the Minister of Health on medicines safety issues, concluded that they were no better at treating pain than taking full dose paracetamol.

They could also cause additional side effects to those caused by paracetamol used at recommended doses, and were dangerous in overdose, or if they were taken with alcohol.

Medsafe group manager Stewart Jessamine said the withdrawal would be gradual to allow time for the safe transfer of patients to alternative treatments.

Medicines containing dextropropoxyphene have been withdrawn in several other countries, most notably the United Kingdom. The European Medicines Agency and Singapore have recently announced that they are also withdrawing these medicines.

When dextropropoxyphene was withdrawn in the United Kingdom it was replaced with other pain killers, mostly by paracetamol alone, codeine alone, or a combination of codeine and paracetamol.

Dr Jessamine said any patient who was currently being treated with Paradex or Capadex should continue to take their medicines. Those who regularly take them would need to see their GP to discuss alternative treatment options.

NZPA

Comments [9]

Tony
16 Mar 2010 3:13p.m.

I have been on Digesic followed by the generic Paradex for 30 years for some effective control of clustered migraines and then for pain control after a knee joint replacement. I should mention that post-operative treatment of morphine gave no relief at all and I discharged myself within 24 hours to avail myself of Paradex which gave me immediate relief and has continued to do so as the operation was not completely successful. I see that the MARC meeting voted against Paradex 14/12 so just one lousey vote has condemned 78,000 people to a miserable future who will, no doubt, take this into consideration at the ballot box. It may be of interest to mention that when Britain banned Co-Proxamol in 2005, those on this Paradex equivalent were given until 2008 to adjust but to adjust to what? Personally, I find like the rest of you that paracetamol to be of no more use than powdered chalk, codeine useless and the same for Acupan and the expensive Tramadol. Do the MARC people really know what they are about?

MargoJH
12 Mar 2010 7:34p.m.

Those of us that cannot use codeine will just be left to endure the pain or switch to something that is more addictive. For me it probably will see me loose my job as I will not be able to work without effective pain relief. Back to the Invalids Benefit which will cost the Govt more than paradex

kevan
20 Feb 2010 12:37p.m.

Hi people, I have been on Paradex for about 18years because of low back and leg pain. This helps about 60% of the pain and the ONLY way I'm addicted is, THAT IT WORKS, no real other side affects. If Paradex is taken away I'm left going to stuff that contains morphine ect that is bound to make me dependent.Codeine gives me headaches and I have tried most of the other pain killers with no joy. What's next for us??

Elizabeth
16 Feb 2010 10:22p.m.

I suffer long term chronic pain, the only relief i have had in 14 years is paradex, yes i have tried all those other things, they are like eating jelly beans, and totally useless in treating my chronic pain, frankly how they came up with the load of rubbish about its effectivness is unbelievable. I am frightened about the future and facing uncontrolled pain again.

Herb
16 Feb 2010 5:39p.m.

Thanks a lot!!!! The powers that be appear not to suffer a lot of pain. Panadol is useless and codiene can bind you up. Paradex has worked for me long term and I have never had any problems with it. Why dont they ask the people who take Paradex whether they can take anything else in place of it???? I cant.

Nicola
16 Feb 2010 10:29a.m.

my mum just told me about paradex being removed. I have fibromyalgia and the pain is so sore. I was just put onto paradex about a month ago and it helps about 75% of the time. I have been on voltaren/celebrex/tramdol(thats a really expense drug)and nurofen. Codeine makes me puke. Taking panadol/paracetamol by itself to me is like taking a tiktak. i hope there is something else that will work for me. My dr basically said to just not be stressed and live with the pain. I am seeing a diferent dr now so i hope shes better.

MargoJH
09 Feb 2010 7:39p.m.

Taking paracetamol alone works about as good as Lollies. Tried a combination of Panadol & codeine recently. I did get pain relief but it was replaced with a nagging headache. Codeine also seemed to mess with my sleep. Not sure what I will do now.

Angel
09 Feb 2010 7:04p.m.

Oops, forgot to say that max dose of Voltaren combined with Paradex was more effective than max dose of Voltaren combined with max dose of paracetamol.

Angel
09 Feb 2010 6:22p.m.

So what does that mean for the 10% of Caucasians that cannot metabolise codeine, so use dextropropoxyphene instead? A CYP2D6 enzyme deficiency (which means codeine isn't metabolised) also decreases the amount of paracetamol you can safely take, so the Paradex (with just 325mg of paracetamol) was perfect for relieving the pain that max doses of Voltaren combined with 1000mg doses of paracetamol alone couldn't budge.

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