Video: Debate rages over sugar substitute

We found none. Instead, the label was in unknown spots in the chromatograms, which plainly indicates that the incorporation of label into DNA and protein was NOT through the incorporation of methyl groups, i.e. the one-carbon folate pathway. Other ways of label incorporation should explain the attachment of the label. The most logical explanation (justified by innumerable studies that show that formaldehyde attaches to protein and other molecules) was that aspartame-derived formaldehyde was chemically bound to protein and DNA, inactivating (embalming, in fact) proteins and altering DNA structure causing mutations.

The experimental studies show that the theory is faulty. No counter-experiments were published showing our possible "errors", nor the theory of folate pathway incorporation has been proved experimentally (it is fairly easy to demonstrate, it only needs to be true, however). This is why I felt insulted. It is an insult to the intelligence of anybody with even a thin varnish of scientific knowledge to discard proven facts and stick to self-fulfilling harebrained theories. If what the aspartame lovers say about the fate of aspartame carbon is true, why nobody has proved it experimentally? It is easy to carry out and much less expensive than hiring lawyers to defend bad science with top dollar legal expertise

I used as heading the famous initial words of the second Catilinary by Cicero, which I remember from my early high-school Latin. Since probably most Americans were lucky enough not to study Latin when 10-11 years old, I provide an approximate translation: "Up to when do you, Catilina, will abuse our patience?", substitute Catilina for the present aspartame producers and probably it fits very well the picture.
Good luck on the banning of this menace to our collective health.
Best regards,

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Dr. Maria Alemany
Departament de Nutrici i Bromatologia
Facultat de Biologia, Universitat de Barcelona

continued: This is explained in elementary physiology and biochemistry courses, it is unbelievable that this is maintained as a "serious" scientific position by somebody that got a PhD, unless this is not a discourse of science but of economy.

Theories are nice, but have to be proved true. The one Dr. Garst exposes here is that maintained by pro-aspartame fellows for decades. This is how they explained the incorporation of aspartame label into protein and DNA in the earliest experiments on aspartame using tracers that were published (none was published by this group thereafter). This theory fits very well with the story of a harmless aspartame, but it has been proven untrue. We did it, and this is why our study was so damaging. If the theory recycled by Dr. Garst were true, then, the carbon of the methyl alcohol of aspartame would enter the one-carbon path mediated by tetrahydrofolate, this can be done via formaldehyde or via formate. These one-carbon units may be processed (depending on demand) to methyl groups, such as those found in carnitine, thymine and methionine (the only amino acid that can get back methyl groups in mammals), thus explaining the presence of label in protein (methionine) or DNA (thymine). We gave labeled aspartame to rats, and got their DNA and protein from a number of tissues, and found large proportions of label. So far no differences with the Aspartame-lovers theory. However, we hydrolyzed the protein and DNA and looked for label in thymine iand found large proportions of label. So far no differences with the Aspartame-lovers theory. However, we hydrolyzed the protein and DNA and looked for label in thymine in DNA and methionine in protein. We found none.

If that were the case, why not get the FDA approval for aspartame as a drug/vitamin substitute? This is an outright fallacy (or better said bull-manure).

Third. Please, not again the tale of the methyl-esters of pectins! It has been proved to nausea that most of the methyl-alcohol esters of uronic acids remain esterified through intestinal passage, and that freed in the large intestine by the action of the flora is majoritarily and keenly used by these microbes for their profit. The remaining methyl alcohol leaving the intestine is largely detoxified by the liver (this is a physiological mechanism well known and proved effective for millennia). Aspartame, however, is not fully hydrolyzed in the intestine, being absorbed in part intact. After the intestine-portal vein-liver trap is surpassed, the body protection against methanol wanes, and the tiny liberation of methanol in tissues yields little amounts of formaldehyde that cause serious damage, precisely because it behaves very differently from the natural products methanol. Even in cases of wood-alcohol (methanol) intoxication, the liver helps to stem the overflow of toxic. Methanol inhalation or injection is much more dangerous, because it goes directly into the bloodstream and tissues jumping the liver barrier. This is explained in elementary physiology and biochemistry courses, it is unbelievable that this is maintained as a "serious" scientific position by somebody that got a PhD, unless this is not a discourse of science but of economy.

part 5 continued